Step 1: In vivo PDX Drug Sensitivity Biomarkers

Step 2: CCEA analysis of drug sensitivity biomarkers

Step 3: Builing a multi-gene expression model for predictin a clinical response to the drug of interest

Step 3-1: Training Random Forest-based model (PDXGEM) training

Step 3-2: Validation of PDXGEM on an indepenent patient cohort

Step 3: Model validation